Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.

Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.

Utilizing ENU mutagenesis, we identified a mutant mouse with elevated platelets. Genetic mapping localized the mutation to an interval on chromosome 19 that encodes the Jak2 tyrosine kinase. We identified a A3056T mutation resulting in a premature stop codon within exon 19 of Jak2 (Jak2(K915X)), res...

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Bibliographic Details
Main Authors: Nicole M Anderson, Mojib Javadi, Elizabeth Berndl, Zorana Berberovic, Monica L Bailey, Kai Huang, Ann M Flenniken, Lucy R Osborne, S Lee Adamson, Janet Rossant, Christin Carter-Su, Chen Wang, Kelly M McNagny, Robert F Paulson, Mark D Minden, William L Stanford, Dwayne L Barber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3783367?pdf=render

Internet

http://europepmc.org/articles/PMC3783367?pdf=render

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