Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway

Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway

Background: Osteopontin (OPN) is highly expressed in colorectal cancer (CRC) and is associated with disease progression in vivo. High levels of OPN have been demonstrated to predict low survival rates in CRC. Autophagy is a process of self-digestion, which is thought to play a significant role in ca...

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Bibliographic Details
Main Authors: Ren-hong Huang, Ying-jun Quan, Jin-hong Chen, Ting-feng Wang, Ming Xu, Min Ye, Hao Yuan, Chong-jie Zhang, Xiao-jian Liu, Zhi-jun Min
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Osteopontin
Autophagy
Proliferation
Migration
Invasion
Apoptosis
Colorectal cancer
P38 MAPK pathway
Online Access:http://www.karger.com/Article/FullText/471933

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http://www.karger.com/Article/FullText/471933

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