UNC93B1 mediates host resistance to infection with Toxoplasma gondii.

UNC93B1 mediates host resistance to infection with Toxoplasma gondii.

UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. We found that the triple deficient '3d' mice, which lack functional UNC93B1, are hy...

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Bibliographic Details
Main Authors: Mariane B Melo, Pia Kasperkovitz, Anna Cerny, Stephanie Könen-Waisman, Evelyn A Kurt-Jones, Egil Lien, Bruce Beutler, Jonathan C Howard, Douglas T Golenbock, Ricardo T Gazzinelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2928809?pdf=render

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http://europepmc.org/articles/PMC2928809?pdf=render

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