Sequence- and interactome-based prediction of viral protein hotspots targeting host proteins: a case study for HIV Nef.

Virus proteins alter protein pathways of the host toward the synthesis of viral particles by breaking and making edges via binding to host proteins. In this study, we developed a computational approach to predict viral sequence hotspots for binding to host proteins based on sequences of viral and ho...

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Bibliographic Details
Main Authors: Mahdi Sarmady, William Dampier, Aydin Tozeren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3125164?pdf=render