Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans

Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans

Background: Regulatory T (Treg) cells are necessary for the maintenance of allogenic pregnancy. However, the repertoire of effector Treg cells at the feto-maternal interface in human pregnancy remains unknown. Our objective was to study T cell receptor (TCR) repertoires of Treg cells during pregnanc...

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Bibliographic Details
Main Authors: Sayaka Tsuda, Xiaoxin Zhang, Hiroshi Hamana, Tomoko Shima, Akemi Ushijima, Kei Tsuda, Atsushi Muraguchi, Hiroyuki Kishi, Shigeru Saito
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
effector regulatory T cell
human pregnancy
miscarriage
preeclampsia
regulatory T cell
T cell repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01934/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01934/full

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