Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model

Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model

Adolescence is a period of vulnerability for the maturation of gray matter (GM) and also for the onset of psychiatric disorders such as major depressive disorder (MDD), bipolar disorder and schizophrenia. Chronic neuroinflammation is considered to play a role in the etiology of these illnesses. Howe...

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Main Authors: Lukas Penninck, El Chérif Ibrahim, Eric Artiges, Victor Gorgievski, Sylvane Desrivières, Severine Farley, Irina Filippi, Carlos E. A. de Macedo, Raoul Belzeaux, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Julien Grenier, Gunter Schumann, Marie-Laure Paillère Martinot, Eleni T. Tzavara, Jean-Luc Martinot, for the IMAGEN Consortium
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Systems Neuroscience
Subjects:
immunity genes
psychiatric symptoms
adolescence
MRI
childhood maltreatment
Online Access:https://www.frontiersin.org/articles/10.3389/fnsys.2021.725413/full

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https://www.frontiersin.org/articles/10.3389/fnsys.2021.725413/full

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