Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibody

Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibody

Dengue fever is caused by four different serotypes of dengue virus (DENV) which is the leading cause of worldwide arboviral diseases in humans. Virus-like particles (VLPs) containing flavivirus prM/E proteins have been demonstrated to be a potential vaccine candidate; however, the structure of dengu...

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Bibliographic Details
Main Authors: Wen-Fan Shen, Jedhan Ucat Galula, Jyung-Hurng Liu, Mei-Ying Liao, Cheng-Hao Huang, Yu-Chun Wang, Han-Chung Wu, Jian-Jong Liang, Yi-Ling Lin, Matthew T Whitney, Gwong-Jen J Chang, Sheng-Ren Chen, Shang-Rung Wu, Day-Yu Chao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
dengue
virus-like particle
cryoEM
broad antibody response
vaccine
Online Access:https://elifesciences.org/articles/38970

Internet

https://elifesciences.org/articles/38970

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