ATM‐Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions

ATM‐Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions

Abstract Repair of DNA double‐strand breaks (DSBs) is essential for genome integrity, and is accompanied by transcriptional repression at the DSB regions. However, the mechanisms how DNA repair induces transcriptional inhibition remain elusive. Here, it is identified that BRD7 participates in DNA da...

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Bibliographic Details
Main Authors: Kaishun Hu, Yu Li, Wenjing Wu, Limin Xie, Haiyan Yan, Yuexin Cai, Dong Chen, Qiongchao Jiang, Lehang Lin, Zhen Chen, Jian‐You Liao, Yin Zhang, H. Phillip Koeffler, Dong Yin, Erwei Song
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Advanced Science
Subjects:
ATM
BRD7
NuRD
PRC2
transcriptional repression
Online Access:https://doi.org/10.1002/advs.202000157

Internet

https://doi.org/10.1002/advs.202000157

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