The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils

The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils

Helicobacter pylori is highly adapted to humans and evades host immunity to allow its lifelong colonization. However, the H. pylori mouse model is artificial for H. pylori, and few adapted strains allow gastric colonization. Here, we show that human or CEACAM-humanized, but not mouse neutrophils are...

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Bibliographic Details
Main Authors: Ina-Kristin Behrens, Benjamin Busch, Hellen Ishikawa-Ankerhold, Pia Palamides, John E. Shively, Cliff Stanners, Carlos Chan, Nelly Leung, Scott Gray-Owen, Rainer Haas
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
helicobacter pylori
cag-type iv secretion system
caga translocation
tyrosine-phosphorylation
phagocytosis
neutrophils
pmns
humanized ceacam myeloid cells
ceacam
ceacam-humanized mice
caga
helicobacter
Online Access:https://doi.org/10.1128/mBio.03256-19

Internet

https://doi.org/10.1128/mBio.03256-19

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