Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein

Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein

Abstract Lipid peroxidation is a key to a portfolio of neurodegenerative diseases and plays a central role in α-synuclein (α-syn) toxicity, mitochondrial dysfunction and neuronal death, all key processes in the pathogenesis of Parkinson’s disease (PD). Polyunsaturated fatty acids (PUFAs) are importa...

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Bibliographic Details
Main Authors: M. Flint Beal, Jayandra Chiluwal, Noel Y. Calingasan, Ginger L. Milne, Mikhail S. Shchepinov, Victor Tapias
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Acta Neuropathologica Communications
Subjects:
Polyunsaturated fatty acids
Lipid peroxidation
α-Synuclein
Gene therapy
Mitochondria
Oxidative stress
Online Access:https://doi.org/10.1186/s40478-020-01090-6

Internet

https://doi.org/10.1186/s40478-020-01090-6

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