High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3

High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3

Abstract Background Oxidative stress is a common cause of neurodegeneration and plays a central role in retinal degenerative diseases. Heme oxygenase-1 (HMOX1) is a redox-regulated enzyme that is induced in neurodegenerative diseases and acts against oxidative stress but can also promote cell death,...

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Bibliographic Details
Main Authors: Huirong Li, Bo Liu, Lili Lian, Jiajia Zhou, Shengjin Xiang, Yifan Zhai, Yu Chen, Xiaoyin Ma, Wencan Wu, Ling Hou
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Neurodegeneration
Subjects:
Photoreceptor degeneration
Antioxidant enzyme
Recombinant adeno-associated virus
Endoplasmic reticulum stress
CHOP pathway
Online Access:https://doi.org/10.1186/s13024-021-00437-4

Internet

https://doi.org/10.1186/s13024-021-00437-4

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