Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child

Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child

Mucosal-associated invariant T (MAIT) cells are unconventional CD3+CD161high T lymphocytes that recognize vitamin B2 (riboflavin) biosynthesis precursor derivatives presented by the MHC-I related protein, MR1. In humans, their T cell receptor is composed of a Vα7.2-Jα33/20/12 chain, combined with a...

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Bibliographic Details
Main Authors: Liana Ghazarian, Sophie Caillat-Zucman, Véronique Houdouin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
mucosal-associated invariant T cells
invariant T cells
innate immunity
antimicrobial defense
riboflavin
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01837/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01837/full

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