FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Abstract Background Chronic low-grade inflammation and oxidative stress play important roles in the development of obesity-induced cardiac hypertrophy. Here, we investigated the role of Fibronectin type III domain containing 5 (FNDC5) in cardiac inflammation and oxidative stress in obesity-induced c...

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Bibliographic Details
Main Authors: Zhi Geng, Wen-Yong Fan, Bing Zhou, Chao Ye, Ying Tong, Ye-Bo Zhou, Xiao-Qing Xiong
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Translational Medicine
Subjects:
FNDC5
Cardiac hypertrophy
Obesity
Inflammation
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12967-019-1857-8

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http://link.springer.com/article/10.1186/s12967-019-1857-8

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