Transcriptional Repression and Protein Degradation of the Ca2+-Activated K+ Channel KCa1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells

Transcriptional Repression and Protein Degradation of the Ca2+-Activated K+ Channel KCa1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells

The large-conductance Ca2+-activated K+ channel KCa1.1 plays an important role in the promotion of breast cancer cell proliferation and metastasis. The androgen receptor (AR) is proposed as a therapeutic target for AR-positive advanced triple-negative breast cancer. We herein investigated the effect...

Full description

Bibliographic Details
Main Authors: Anowara Khatun, Motoki Shimozawa, Hiroaki Kito, Mayu Kawaguchi, Mayu Fujimoto, Moe Ri, Junko Kajikuri, Satomi Niwa, Masanori Fujii, Susumu Ohya
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
Ca2+-activated K+ channel
KCa1.1
antiandrogen
androgen receptor
breast cancer
ubiquitin E3 ligase
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00312/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00312/full

Similar Items