Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

We present the crystal structure of the junction-resolving enzyme GEN1 bound to DNA at 2.5 Å resolution. The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution. The functional unit in the crystal is a monom...

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Bibliographic Details
Main Authors: Yijin Liu, Alasdair D.J. Freeman, Anne-Cécile Déclais, Timothy J. Wilson, Anton Gartner, David M.J. Lilley
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
DNA-protein interactions
DNA recombination
DNA repair
Holliday junction
X-ray crystallography
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715013571

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http://www.sciencedirect.com/science/article/pii/S2211124715013571

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