The transcription factor Hey and nuclear lamins specify and maintain cell identity

The transcription factor Hey and nuclear lamins specify and maintain cell identity

The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult Drosophila midgut. Lineage tracing established that Hey-deficient ECs are unable...

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Bibliographic Details
Main Authors: Naama Flint Brodsly, Eliya Bitman-Lotan, Olga Boico, Adi Shafat, Maria Monastirioti, Manfred Gessler, Christos Delidakis, Hector Rincon-Arano, Amir Orian
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
cell identity
gene regulation
nuclear organization
hey
lamin
ageing
Online Access:https://elifesciences.org/articles/44745

Internet

https://elifesciences.org/articles/44745

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