Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence

Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence

Cryptococcus is a fungal pathogen that kills an estimated quarter of a million individuals yearly and is the most common cause of nonviral meningitis in the United States. The fungus is carried in about 10% of the adult population and, after reactivation, causes disease in a wide variety of immunosu...

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Bibliographic Details
Main Authors: Yoon-Dong Park, Joseph N. Jarvis, Guowu Hu, Sarah E. Davis, Jin Qiu, Nannan Zhang, Christopher Hollingsworth, Angela Loyse, Paul J. Gardina, Tibor Valyi-Nagy, Timothy G. Myers, Thomas S. Harrison, Tihana Bicanic, Peter R. Williamson
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mBio
Subjects:
CAC2
CAF-1
Cryptococcus neoformans
STL1
TOR pathway
VAD1
Online Access:https://doi.org/10.1128/mBio.02353-18

Internet

https://doi.org/10.1128/mBio.02353-18

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