Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine.

Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine.

The worldwide burden of malaria remains a major public health problem due, in part, to the lack of an effective vaccine against the Plasmodium falciparum parasite. An effective vaccine will most likely require the induction of antigen specific CD8(+) and CD4(+) T-cells as well as long-lasting antibo...

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Bibliographic Details
Main Authors: Stephen A Kaba, Margaret E McCoy, Tais A P F Doll, Clara Brando, Qin Guo, Debleena Dasgupta, Yongkun Yang, Christian Mittelholzer, Roberta Spaccapelo, Andrea Crisanti, Peter Burkhard, David E Lanar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3483151?pdf=render

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http://europepmc.org/articles/PMC3483151?pdf=render

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