Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth

Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth

Colorectal carcinoma (CRC) is a major cause of morbidity and mortality in Western countries. It has so far been molecularly defined mainly by alterations of the Wnt pathway. We show here for the first time that aberrant activities of the signal transducer and activator of transcription STAT3 active...

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Bibliographic Details
Main Authors: Florian M. Corvinus, Carina Orth, Richard Moriggl, Svetlana A. Tsareva, Stefan Wagner, Edith B. Pfitzner, Daniela Baus, Roland Kaufman, Lukas A. Huber, Kurt Zatloukal, Hartmut Beug, Peter Öhlschläger, Alexander Schütz, Karl-Jürgen Halbhuber, Karlheinz Friedrich
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Colorectal cancer
JAWSTAT pathway
STAT3
xenograft
cell proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800752

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http://www.sciencedirect.com/science/article/pii/S1476558605800752

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