Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.

Memory loss is one of the hallmark symptoms of Alzheimer's disease (AD). It has been proposed that soluble amyloid-beta (Abeta) oligomers acutely impair neuronal function and thereby memory. We here report that natural Abeta oligomers acutely impair contextual fear memory in mice. A natural Abe...

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Bibliographic Details
Main Authors: Kara A Kittelberger, Fabrizio Piazza, Giuseppina Tesco, Leon G Reijmers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3251597?pdf=render