High-level expression of biologically active human follicle stimulating hormone in the Chinese hamster ovary cell line by a pair of tricistronic and monocistronic vectors.

High-level expression of biologically active human follicle stimulating hormone in the Chinese hamster ovary cell line by a pair of tricistronic and monocistronic vectors.

Recombinant human follicle stimulating hormone (FSH), produced in Chinese hamster ovary (CHO) cells, is widely used for treatment of fertility disorders and is subject to biosimilars development. Cell lines with high specific productivities may simplify the FSH production process. Here, we used our...

Full description

Bibliographic Details
Main Authors: Nadezhda A Orlova, Sergey V Kovnir, Yulia A Khodak, Mikhail A Polzikov, Victoria A Nikitina, Konstantin G Skryabin, Ivan I Vorobiev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0219434

Internet

https://doi.org/10.1371/journal.pone.0219434

Similar Items