Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry

Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry

Due to its 4 carbonic acid groups being available for bioconjugation, the cyclen tetraphosphinate chelator DOTPI, 1,4,7,10-tetraazacyclododecane-1,4,7, 10-tetrakis[methylene(2-carboxyethylphosphinic acid)], represents an ideal scaffold for synthesis of tetrameric bioconjugates for labeling with radi...

Full description

Bibliographic Details
Main Authors: Alexander Wurzer, Adrienn Vágner, Dávid Horváth, Flóra Fellegi, Hans-Jürgen Wester, Ferenc K. Kálmán, Johannes Notni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Chemistry
Subjects:
Huisgen-reaction
potentiometry
spectrophotometry
phosphinate
radiopharmaceuticals
endoradiotherapy
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00107/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00107/full

Similar Items