Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opsonophagocytic killing. The adenylate cyclase toxin (CyaA) of <i>Bordetella pertussis</i> and the edema toxin (ET) of <i>Bacillus anthracis</i> are both calmodulin-activated toxin...

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Bibliographic Details
Main Authors: Shakir Hasan, Waheed Ur Rahman, Peter Sebo, Radim Osicka
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Toxins
Subjects:
3′,5′-cyclic adenosine monophosphate (cAMP)
adenylate cyclase toxin
edema toxin
opsonophagocytosis
phagocytes
Syk
Vav
Pyk2
signaling pathway
Online Access:https://www.mdpi.com/2072-6651/11/6/362

Internet

https://www.mdpi.com/2072-6651/11/6/362

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