Local delivery of dinutuximab from lyophilized silk fibroin foams for treatment of an orthotopic neuroblastoma model

Abstract Immunotherapy targeting GD2 is a primary treatment for patients with high‐risk neuroblastoma. Dinutuximab is a monoclonal antibody with great clinical promise but is limited by side effects such as severe pain. Local delivery has emerged as a potential mechanism to deliver higher doses of t...

Full description

Bibliographic Details
Main Authors: Kimberly J. Ornell, Jordan S. Taylor, Jasmine Zeki, Naohiko Ikegaki, Hiroyuki Shimada, Jeannine M. Coburn, Bill Chiu
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Cancer Medicine
Subjects:
Online Access:https://doi.org/10.1002/cam4.2936