Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression.

The role of PD-1 expression on CD4 T cells during HIV infection is not well understood. Here, we describe the differential expression of PD-1 in CD127high CD4 T cells within the early/intermediate differentiated (EI) (CD27highCD45RAlow) T cell population among uninfected and HIV-infected subjects, w...

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Bibliographic Details
Main Authors: Robert M Paris, Constantinos Petrovas, Sara Ferrando-Martinez, Eirini Moysi, Kristin L Boswell, Eva Archer, Takuya Yamamoto, David Ambrozak, Joseph P Casazza, Richard Haubrich, Mark Connors, Julie Ake, Jerome H Kim, Richard A Koup
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4692060?pdf=render