Role of Human Mesangial-Tubular Crosstalk in Secretory IgA-Induced IgA Nephropathy

Role of Human Mesangial-Tubular Crosstalk in Secretory IgA-Induced IgA Nephropathy

Background: IgA nephropathy (IgAN) is characterized by the mesangial deposition of pathogenic IgA. We previously detected the deposition of pathogenic secretory IgA (SIgA) in the mesangium of about one-third of IgAN patients. Tubulointerstitial injury has an important role in the development of IgAN...

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Bibliographic Details
Main Authors: Junjun Zhang, Ruwen Zhou, Yiming Mi, Zhangsuo Liu, Bo Huang, Ruxue Guo, Panfei Wang, Songxia Quan, Yali Zhou
Format: Article
Language:English
Published: Karger Publishers 2021-04-01
Series:Kidney & Blood Pressure Research
Subjects:
iga nephropathy
mucosal immunity
secretory iga
mesangial-tubular crosstalk
Online Access:https://www.karger.com/Article/FullText/514183

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https://www.karger.com/Article/FullText/514183

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