Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver

Abstract Sexual dimorphism in gene regulation, including DNA methylation, is the main driver of sexual dimorphism in phenotypes. However, the questions of how and when sex shapes DNA methylation remain unresolved. Recently, using mice with different combinations of genetic and phenotypic sex, we ide...

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Bibliographic Details
Main Authors: Najla AlOgayil, Klara Bauermeister, Jose Hector Galvez, Varun S. Venkatesh, Qinwei Kim-wee Zhuang, Matthew L. Chang, Rachel A. Davey, Jeffrey D. Zajac, Kinuyo Ida, Akihide Kamiya, Teruko Taketo, Guillaume Bourque, Anna K. Naumova
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93216-6

Internet

https://doi.org/10.1038/s41598-021-93216-6

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