Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair

Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair

Summary: Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering ∼95% of the surface area, are responsible for gas exchange, whereas AT2 serve multiple functions, including alveolar repair through proliferation and di...

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Bibliographic Details
Main Authors: Johanna Finn, Kilian Sottoriva, Kostandin V. Pajcini, Jan K. Kitajewski, Chang Chen, Wei Zhang, Asrar B. Malik, Yuru Liu
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719302177

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http://www.sciencedirect.com/science/article/pii/S2211124719302177

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