Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr‐Cas9

Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr‐Cas9

Abstract Background Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submu...

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Bibliographic Details
Main Authors: Elise Dreano, Marc Bacchetta, Juliette Simonin, Louise Galmiche, Claire Usal, Lotfi Slimani, Jérémy Sadoine, Laurent Tesson, Ignacio Anegon, Jean‐Paul Concordet, Aurélie Hatton, Lucile Vignaud, Danielle Tondelier, Isabelle Sermet‐Gaudelus, Marc Chanson, Charles‐Henry Cottart
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Animal Models and Experimental Medicine
Subjects:
animal models
CFTR channel activity
CFTR modulators
cystic fibrosis
primary cultures
rat
Online Access:https://doi.org/10.1002/ame2.12091

Internet

https://doi.org/10.1002/ame2.12091

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