Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats
Hypoxia-inducible factor-1 (HIF-1) plays an essential role in cerebral ischemia as a proapoptotic factor. We hypothesized that HIF-1α siRNA can protect the brain from ischemic damage by inhibiting HIF-1α induced apoptotic pathway at the RNA level in a rat focal ischemic model. Results showed that tr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-03-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996108003161 |