Hypoxia-Induced Glioma-Derived Exosomal miRNA-199a-3p Promotes Ischemic Injury of Peritumoral Neurons by Inhibiting the mTOR Pathway

The underlying molecular mechanisms that the hypoxic microenvironment could aggravate neuronal injury are still not clear. In this study, we hypothesized that the exosomes, exosomal miRNAs, and the mTOR signaling pathway might be involved in hypoxic peritumoral neuronal injury in glioma. Multimodal...

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Bibliographic Details
Main Authors: Jian-Lan Zhao, Bo Tan, Gong Chen, Xiao-Ming Che, Zhuo-Ying Du, Qiang Yuan, Jian Yu, Yi-Rui Sun, Xiao-Mu Li, Jin Hu, Rong Xie
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/5609637