Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma.

Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma.

Levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, are increased in lung, sputum, exhaled breath condensate and plasma samples from asthma patients. ADMA is metabolized primarily by dimethylarginine dimethylaminohydrolase 1 (DDAH1) and DDAH2. We determine...

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Bibliographic Details
Main Authors: Kayla G Kinker, Aaron M Gibson, Stacey A Bass, Brandy P Day, Jingyuan Deng, Mario Medvedovic, Julio A Landero Figueroa, Gurjit K Khurana Hershey, Weiguo Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3894860?pdf=render

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http://europepmc.org/articles/PMC3894860?pdf=render

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