Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway. We report that netarsudil, a rho-kinase inhibitor, decreased glucocorticoid-induced ocular...

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Bibliographic Details
Main Authors: Guorong Li, Chanyoung Lee, A Thomas Read, Ke Wang, Jungmin Ha, Megan Kuhn, Iris Navarro, Jenny Cui, Katherine Young, Rahul Gorijavolu, Todd Sulchek, Casey Kopczynski, Sina Farsiu, John Samples, Pratap Challa, C Ross Ethier, W Daniel Stamer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
steroid glaucoma
glaucoma medications
trabecular meshwork
fibrosis
contractility
Online Access:https://elifesciences.org/articles/60831

Internet

https://elifesciences.org/articles/60831

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