Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi

For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been studied. In recent years, the thymic phenotype o...

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Bibliographic Details
Main Authors: Juan José Muñoz, Javier García-Ceca, Sara Montero-Herradón, Beatriz Sánchez del Collado, David Alfaro, Agustín Zapata
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Endocrinology
Subjects:
Eph
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00135/full