Neuronal antibody biomarkers for Sydenham's chorea identify a new group of children with chronic recurrent episodic acute exacerbations of tic and obsessive compulsive symptoms following a streptococcal infection.

Neuronal antibody biomarkers for Sydenham's chorea identify a new group of children with chronic recurrent episodic acute exacerbations of tic and obsessive compulsive symptoms following a streptococcal infection.

Several autoantibodies (anti-dopamine 1 (D1R) and 2 (D2R) receptors, anti-tubulin, anti-lysoganglioside-GM1) and antibody-mediated activation of calcium calmodulin dependent protein kinase II (CaMKII) signaling activity are elevated in children with Sydenham's chorea (SC). Recognizing proposed...

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Bibliographic Details
Main Authors: Harvey S Singer, Adda Mascaro-Blanco, Kathy Alvarez, Christina Morris-Berry, Ivana Kawikova, Hilla Ben-Pazi, Carol B Thompson, Syed F Ali, Edward L Kaplan, Madeleine W Cunningham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368605?pdf=render

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http://europepmc.org/articles/PMC4368605?pdf=render

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