Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

Abstract Background The advents of novel immunotherapies have revolutionized the treatment of cancer. Adoptive cellular therapies using chimeric antigen receptor T (CAR-T) cells have achieved remarkable clinical responses in B cell leukemia and lymphoma but the effect on solid tumors including lung...

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Bibliographic Details
Main Authors: Junlin Yao, Dalam Ly, Dzana Dervovic, Linan Fang, Jong Bok Lee, Hyeonjeong Kang, Yu-Hui Wang, Nhu-An Pham, Hongming Pan, Ming-Sound Tsao, Li Zhang
Format: Article
Language:English
Published: BMJ Publishing Group 2019-01-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Adoptive cellular therapy
Double negative T cells
Lung cancer
IL-15
Online Access:http://link.springer.com/article/10.1186/s40425-019-0507-2

Internet

http://link.springer.com/article/10.1186/s40425-019-0507-2

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