Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells

Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells

Vasopressin V2 receptor (V2R) antagonists (vaptans) are a new generation of diuretics. Compared with classical diuretics, vaptans promote the excretion of retained body water in disorders in which plasma vasopressin concentrations are inappropriately high for any given plasma osmolality. Under these...

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Bibliographic Details
Main Authors: Annarita Di Mise, Maria Venneri, Marianna Ranieri, Mariangela Centrone, Lorenzo Pellegrini, Grazia Tamma, Giovanna Valenti
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:International Journal of Molecular Sciences
Subjects:
v2r
vaptans
vasopressin
lixivaptan
aquaporin-2
Online Access:https://www.mdpi.com/1422-0067/21/1/183

Internet

https://www.mdpi.com/1422-0067/21/1/183

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