Revisiting CD8 T-cell ‘Memory Inflation’: New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

Revisiting CD8 T-cell ‘Memory Inflation’: New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

Murine models of cytomegalovirus (CMV) infection have revealed an exceptional kinetics of the immune response. After resolution of productive infection, transient contraction of the viral epitope-specific CD8 T-cell pool was found to be followed by a pool expansion specific for certain viral epitope...

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Bibliographic Details
Main Authors: Rafaela Holtappels, Kirsten Freitag, Angelique Renzaho, Sara Becker, Niels A.W. Lemmermann, Matthias J. Reddehase
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Vaccines
Subjects:
avidity maturation
central memory CD8 T cells (TCM)
cytomegalovirus
effector memory CD8 T cells (TEM)
conventional TEM (cTEM)
inflationary TEM (iTEM)
Online Access:https://www.mdpi.com/2076-393X/8/3/402

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https://www.mdpi.com/2076-393X/8/3/402

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