Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4–1BB)

Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4–1BB)

TRAF2 dependent K63-polyubiquitinations have been recently shown to connect CD137 (4–1BB) stimulation to NF-κB activation. In a search of deubiquitinase enzymes (DUBs) that could regulate such a signaling route, A20 and CYLD were found to coimmunoprecipitate with CD137 and TRAF2 complexes. Indeed, o...

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Bibliographic Details
Main Authors: Arantza Azpilikueta, Elixabet Bolaños, Valerie Lang, Sara Labiano, Maria A. Aznar, Iñaki Etxeberria, Alvaro Teijeira, Maria E. Rodriguez-Ruiz, Jose L. Perez-Gracia, Maria Jure-Kunkel, Juan M. Zapata, Manuel S. Rodriguez, Ignacio Melero
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
deubiquitinases
a20
cyld
cd137(41bb)
traf2
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1368605

Internet

http://dx.doi.org/10.1080/2162402X.2017.1368605

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