Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease

Lysosomal storage disorders (LSD) are characterized by the accumulation of diverse lipid species in lysosomes. Niemann-Pick type A/B (NPA/B) and type C diseases Niemann-Pick type C (NPC) are progressive LSD caused by loss of function of distinct lysosomal-residing proteins, acid sphingomyelinase and...

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Bibliographic Details
Main Authors: Sandra Torres, Elisa Balboa, Silvana Zanlungo, Carlos Enrich, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
Subjects:
mitochondria
lysosomes
cholesterol
sphingolipids
intracellular trafficking
lysosomal disorders
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00982/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00982/full

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