Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies

Abstract Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which makes this lipid a versatile signaling...

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Bibliographic Details
Main Authors: Luiz Henrique Medeiros Geraldo, Tânia Cristina Leite de Sampaio Spohr, Rackele Ferreira do Amaral, Anna Carolina Carvalho da Fonseca, Celina Garcia, Fabio de Almeida Mendes, Catarina Freitas, Marcos Fabio dosSantos, Flavia Regina Souza Lima
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-020-00367-5