Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes

Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes

Phenolic diterpenes present in Rosmarinus officinalis and Salvia officinalis have anti-inflammatory and chemoprotective effects. We investigated the in vitro effects of carnosol (CL), carnosic acid (CA), carnosic acid-12-methylether (CAME), 20-deoxocarnosol and abieta-8,11,13-triene-11,12,20-triol (...

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Bibliographic Details
Main Authors: Joseph Schwager, Nathalie Richard, Ann Fowler, Nicole Seifert, Daniel Raederstorff
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
abietanes
carnosol
chondrocyte
osteoarthritis
murine macrophages
innate immune response
acute inflammation
chronic inflammation
NF-κB signaling pathway and nuclear translocation
Online Access:http://www.mdpi.com/1420-3049/21/4/465

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http://www.mdpi.com/1420-3049/21/4/465

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