Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

Abstract Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer. However, the antineoplastic mechanism of serotonin tr...

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Bibliographic Details
Main Authors: Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang, Feng Bi
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Serotonin
SERT
Tryptophan
mTORC1
Trametinib
Online Access:https://doi.org/10.1186/s13046-021-01971-1

Internet

https://doi.org/10.1186/s13046-021-01971-1

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