Metabolic Fingerprinting of Murine L929 Fibroblasts as a Cell-Based Tumour Suppressor Model System for Methionine Restriction

Metabolic Fingerprinting of Murine L929 Fibroblasts as a Cell-Based Tumour Suppressor Model System for Methionine Restriction

Since Otto Warburg reported in 1924 that cancer cells address their increased energy requirement through a massive intake of glucose, the cellular energy level has offered a therapeutic anticancer strategy. Methionine restriction (MetR) is one of the most effective approaches for inducing low-energy...

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Bibliographic Details
Main Authors: Werner Schmitz, Corinna Koderer, Mohamed El-Mesery, Sebastian Gubik, Rene Sampers, Anton Straub, Alexander Christian Kübler, Axel Seher
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
methionine restriction
caloric restriction
mass spectrometry
LC/MS
liquid chromatography/mass spectrometry
metabolism
Online Access:https://www.mdpi.com/1422-0067/22/6/3039

Internet

https://www.mdpi.com/1422-0067/22/6/3039

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