Ketamine Rescues Hippocampal Reelin Expression and Synaptic Markers in the Repeated-Corticosterone Chronic Stress Paradigm

Ketamine Rescues Hippocampal Reelin Expression and Synaptic Markers in the Repeated-Corticosterone Chronic Stress Paradigm

Depression is the leading cause of disability worldwide, which necessitates novel therapeutics and biomarkers to approach treatment of this neuropsychiatric disorder. To assess potential mechanisms underlying the fast-acting antidepressant actions of ketamine we used a repeated corticosterone paradi...

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Bibliographic Details
Main Authors: Jenessa N. Johnston, Jonathan S. Thacker, Charissa Desjardins, Brian D. Kulyk, Raquel Romay-Tallon, Lisa E. Kalynchuk, Hector J. Caruncho
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
reelin
ketamine
antidepressant
mammalian target of rapamycin
synaptosomes
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.559627/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.559627/full

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