Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing

Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing. Janus kinase (JAK) inhibition with tofacitinib has been demonstrated...

Full description

Bibliographic Details
Main Authors: Timo Gaber, Antonia Clara Katharina Brinkman, Justyna Pienczikowski, Karoline Diesing, Alexandra Damerau, Moritz Pfeiffenberger, Annemarie Lang, Sarah Ohrndorf, Gerd-Rüdiger Burmester, Frank Buttgereit, Paula Hoff
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
tofacitinib
bone healing
hmsc-migration
chondrogenic differentiation
osteogenic differentiation
osteoclast differentiation
Online Access:https://www.mdpi.com/1422-0067/21/3/865

Internet

https://www.mdpi.com/1422-0067/21/3/865

Similar Items