Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD). To assess the immunological effects of this drug on B cells, follicular T helper (Tfh) cells, and peripheral T helper (Tph) cells in patients with NMOSD...

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Bibliographic Details
Main Authors: Ye Liu, Huiming Zhang, Tian-Xiang Zhang, Meng Yuan, Chen Du, Pei Zeng, Zhenning Huang, Dongmei Jia, Guili Yang, Fu-Dong Shi, Chao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
NMOSD
tocilizumab
B cells
T helper cells
PD-1
PD-L
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.703931/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.703931/full

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