Extracellular Matrix Hydrogel Promotes Tissue Remodeling, Arteriogenesis, and Perfusion in a Rat Hindlimb Ischemia Model

Extracellular Matrix Hydrogel Promotes Tissue Remodeling, Arteriogenesis, and Perfusion in a Rat Hindlimb Ischemia Model

Although surgical and endovascular revascularization can be performed in peripheral arterial disease (PAD), 40% of patients with critical limb ischemia do not have a revascularization option. This study examines the efficacy and mechanisms of action of acellular extracellular matrix-based hydrogels...

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Bibliographic Details
Main Authors: Jessica L. Ungerleider, BS, Todd D. Johnson, PhD, Melissa J. Hernandez, BS, Dean I. Elhag, BS, Rebecca L. Braden, MS, Monika Dzieciatkowska, PhD, Kent G. Osborn, DVM, PhD, Kirk C. Hansen, PhD, Ehtisham Mahmud, MD, Karen L. Christman, PhD
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:JACC: Basic to Translational Science
Subjects:
biomaterial
critical limb ischemia
decellularization
hydrogel
injectable
peripheral artery disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16000140

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http://www.sciencedirect.com/science/article/pii/S2452302X16000140

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