Systemic and Intravitreal Antagonism of the TNFR1 Signaling Pathway Delays Axotomy-Induced Retinal Ganglion Cell Loss

Systemic and Intravitreal Antagonism of the TNFR1 Signaling Pathway Delays Axotomy-Induced Retinal Ganglion Cell Loss

Here, we have blocked the signaling pathway of tumor necrosis factor α (TNFα) in a mouse model of traumatic neuropathy using a small cell permeable molecule (R7050) that inhibits TNFα/TNF receptor 1 (TNFR1) complex internalization. Adult pigmented mice were subjected to intraorbital optic nerve crus...

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Bibliographic Details
Main Authors: Fernando Lucas-Ruiz, Caridad Galindo-Romero, Manuel Salinas-Navarro, María Josefa González-Riquelme, Manuel Vidal-Sanz, Marta Agudo Barriuso
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
optic nerve crush
retinal ganglion cells
R7050
BDNF
combinatory therapy
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01096/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01096/full

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