Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats.

Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats.

Glucocorticoid (GC)-based therapies can cause insulin resistance (IR), glucose intolerance, hyperglycemia and, occasionally, overt diabetes. Understanding the mechanisms behind these metabolic disorders could improve the management of glucose homeostasis in patients undergoing GC treatment. For this...

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Bibliographic Details
Main Authors: Alex Rafacho, Luiz M Gonçalves-Neto, Junia C Santos-Silva, Paloma Alonso-Magdalena, Beatriz Merino, Sebastião R Taboga, Everardo M Carneiro, Antonio C Boschero, Angel Nadal, Ivan Quesada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3976288?pdf=render

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http://europepmc.org/articles/PMC3976288?pdf=render

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